Ines de Santiago

Ines is working in the identification of genetic and epigenetic signatures that underly susceptability to breast cancer. Together with the lab of B. Ponder at the CRI, she is exploring to which extent genetic variation in the binding of ERα and co-factors (e.g. FOXA1, GATA3) influences susceptibility to breast cancer as well as response to therapy.

Vita

since 09/2012
Postdoctoral research at Cancer Research UK Cambridge Research Institute.

2007 - 2011
PhD student at CSC-MRC, Imperial College London, Unted Kingdom. Advisors: Prof. Ana Pombo.

2006 - 2007
PhD program in Computational Biology, at Instituto Gulbenkian de Ciencias, Oeiras, Portugal.

2001 - 2006
Degree in Biochemistry. Faculty of Sciences, University of Lisbon, Portugal.

Degrees

Ph.D in Computational Biology and Stem cell biology

Imperial College London, UK.

Degree in Biochemistry
Faculty of Sciences, University of Lisbon, Portugal.

Awards and fellowships

Individual Ph.D Fellowship (2006-2011) Awarded by Fundação para a Ciência e Tecnologia, Portugal.
Ines de Santiago

Ines de Santiago
CR UK - CI
Li Ka Shing Centre
Robinson Way
Cambridge, CB2 0RE, UK
e: first.last@cruk.cam.ac.uk
p: +44 (0) 1223 769 739

Funded by CRUK logo Affiliated with Cambridge University

Publications

  1. de Santiago I* et al., Immuno-phenotypes of PDAC: A Meta-analysis of transcriptional subtypes. BioRxiv. 2017 Oct 5. https://doi.org/10.1101/198903. (*First and corresponding author).
  2. de Santiago I* & Carroll T., ChIP-seq Analysis in R/Bioconductor. Springer Nature. Methods Mol Biol. 2017; 1689:195-226. (*First and corresponding author).
  3. Ferrai C et al., RNA polymerase II primes Polycomb-repressed developmental genes throughout terminal neuronal differentiation. Mol. Syst. Biol. October 2017 vol. 13 no. 10 946
  4. Barbieri M et al., Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells. Nat Struct. Mol Biol. 2017 Jun;24(6):515-524.
  5. Beagrie RA et al., Complex multi-enhancer contacts captured by genome architecture mapping. Nature. 2017 Mar 23;543(7646):519-524.
  6. de Santiago I et al., BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes. Genome Biol. 2017 Feb 24;18(1):39.
  7. Sivakumar S* & de Santiago I* et al., Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer. PLoS Med. 2017 Jan 31;14(1): e1002223. (*Co-first author).
  8. Campbell TM et al., FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness. Carcinogenesis. 2016 Aug;37(8):741-750.
  9. Hilvo M, de Santiago I et al., Accumulated metabolites of hydroxybutyric acid serve as diagnostic and prognostic biomarkers of ovarian carcinomas. Cancer Res. 2016 Feb 15;76(4):796-804.
  10. Castro M, de Santiago I et al., Regulators of genetic risk of breast cancer identified by integrative network analysis. Nat Genet. 2016 Jan;48(1):12-21.
  11. Carroll TS, Liang Z, Salama R, Stark R, de Santiago I*. Impact of artifact removal on ChIP quality metrics in ChIP-seq and ChIP-exo data. Front Genet. 2014 Apr 10;5:75. (*Corresponding author).
  12. Ghoussaini M et al., Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nat Commun. 2014 Sep 23;4:4999.
  13. Martins FC & de Santiago I* et al., Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier. Genome Biol. 2014 Dec 17;15(12):526. (*Co-first author).
  14. Meyer KB et al., Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1. Am J Hum Genet. 2013 Dec 5;93(6):1046-60.
  15. Fletcher et al., Master regulators of FGFR2 signalling and breast cancer risk. Nat Commun. 2013; 4:2464.
  16. de Santiago I, Brookes E, Hebenstreit D, Morris KJ, Carroll T, Lenhard B, Stock JK, Heidemann M, Eick D, Nozaki N, Kimura H, Lenhard B, Ragoussis J, Teichmann SA, Pombo A. Polycomb repression co-associates with a specific RNA polymerase II variant, and is important for metabolic gene regulation in embryonic stem cells. Cell Stem Cell. 2012 Feb 3;10(2):157-70.
  17. Eukaryotic gene regulation in three dimensions and its impact on genome evolution. Babu MM, Janga SC, de Santiago I, Pombo A. Curr Opin Genet Dev. 2008 Dec;18(6):571-82.