OncoNEM - Inferring tumour evolution from single-cell sequencing data
OncoNEM is a probabilistic method for inferring intra-tumor evolutionary lineage trees from somatic single nucleotide variants of single cells.
OncoNEM identifies homogeneous cellular subpopulations and infers their genotypes as well as a tree describing their evolutionary relationships.
Download and Installation
You can download OncoNEM from https://bitbucket.org/edith_ross/onconem
To install this package directly in R type:
library(devtools)
install_bitbucket("edith_ross/oncoNEM")
Reference:
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OncoNEM: inferring tumour evolution from single-cell sequencing data
E. M. Ross, F. Markowetz
Genome Biology (2016) 17:69
PMID:27083415 | doi:10.1186/s13059-016-0929-9
